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The accident took place around 12.30 am in Ramgarh area when the victims, all residents of Ujjain, were returning home after attending a marriage function in Nagda city, Bherugarh police station in-charge Jai C Ram Barde said.
Their vehicle collided head on with a speeding sports utility vehicle (SUV), killing 12 passengers of the van on the spot, he said.
The two injured persons were referred to Indore for treatment, he said.