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Two among the injured are said to be critical, they added.
Kanpur Outer’s Superintendent of Police (SP) Ashtbhuja Prasad Singh said the accident occurred in the Kisan Nagar area when a speeding bus hit a loader, which fell on the other side of the highway, while the bus also overturned and fell into a ditch.
Chief Minister Yogi Adityanath has announced an ex-gratia amount of Rs 2 lakh each to the next of kin of the deceased and ordered an inquiry into the incident.
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GSVM college principal RB Kamal told PTI over the phone that at least 17 people were killed, while five were admitted at the Lala Lajpat Rai (LLR) hospital with serious injuries.
The condition of two was said to be very critical, he said.
A heavy police force, comprising personnel from half-a-dozen police stations, was dispatched to the site of the accident.
The policemen extricated the passengers and found that many of them were already dead.
An official spokesperson in Lucknow said the chief minister has expressed grief over the loss of lives in the road accident in Kanpur and directed senior officials to immediately rush to the spot.
He has announced an ex-gratia amount of Rs 2 lakh each to the kin of the deceased, and asked the district administration to conduct an inquiry into the reasons behind the accident and submit a report, the spokesperson said.
The chief minister has also directed for extending immediate help and ensuring proper treatment to the injured persons.