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The accident happened on Sunday night near Ghazi Ghaat area.
Nineteen people, including 13 from same extended family of Multan were killed in the tragedy, police said.
The injured were shifted to various hospitals by the rescue teams.
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Road accidents are common in Pakistan. Most of the mishaps are caused due to reckless driving and bad roads.
Prime Minister Imran Khan expressed grief and sorrow over the tragic incident, expressing sympathy and condoled with the bereaved families.
He also directed to provide the best medical assistance to the injured passengers.
Punjab Chief Minister Usman Buzdar also condoled over the loss of precious lives in the tragic incident.