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The blast took place in front of the emergency gate of District headquarter hospital Dera Ismail Khan district of the province, Deputy Superintendent of Police Iftikhar Shah said.
At least three persons were killed and ten others sustained injuries, he said.
Immediately, the injured persons were rushed to a nearby hospital.
According to Bomb Disposal Squad officials, around 7 to 8 kilograms of explosive material was used in the blast.
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