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The accident took place near Chikhodra village in Anand district at around 4.30 am when the private luxury bus, which was on way towards Ahmedabad, had pulled over on the roadside after one of its tyres burst, an official from Anand Rural police station said.
While the tyre was being changed, the bus passengers alighted and some of them were waiting in front of the vehicle when a speeding truck hit the bus from behind, the official said.
Five persons died on the spot while one succumbed to injuries in a hospital, he said, adding the bus driver was among the deceased.
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The injured persons were admitted to hospital, the official said.