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Police said that they arrested the men and seized the two vehicles in which the drugs — around 76 kg of ganja and 2.8 kg of hashish oil — were being transported.
The accused are Thrissur natives and were bringing the drugs from Odisha, a senior police officer of the district said.
The official said the accused were caught late Friday night from near the Kuthiran tunnel here by a special anti-narcotics team of the police which was waiting for them based on a tip-off.