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The Kathmandu-bound passenger bus lost control and fell into the Trishuli River at the Ghatbesi locality, The Himalayan Times newspaper reported.
At least seven people, including a woman, died in the accident, according to Gautam KC, Superintendent of Police (SP) at the Dhading District Police Office.
At least 30 passengers were injured in the accident and were rescued by the locals along with the Nepal Police, Armed Police Force and Nepal Army.
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The deceased are yet to be identified, according to the report.
The driver of the bus was arrested by the police.
The death toll is expected to rise, given the injuries the passengers sustained because of the bus plunging into the river.
A team from the Armed Police Force and Disaster Management Training School, Kurintar, Chitwan, was also involved in the rescue operation, the report said.