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The accident happened on Sunday at midnight.
According to police, the accident happened when the bus attached to the Karnataka State Road Transport Corporation (KSRTC) rammed into a truck transporting stones from behind at the Mylapura Gate near Hoskote.
The couple died on the spot and three children were severely injured. The condition of two persons is critical. The injured have been shifted to a private hospital.
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More details were awaited regarding the incident.
(With IANS inputs)