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Kamat, 50, who was suffering from chronic liver disease and secondary infections, was admitted to AIG hospital in Gachibowli, Hyderabad on July 31.
“I will miss you my friend Nishikant Kamat. Rest in peace,” tweeted actor Riteish Deshmukh, who starred in Mr Kamat’s film Lai Bhaari.
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Kamat made his directorial debut with the Marathi film “Dombivali Fast” in 2005. His Bollywood debut was 2008”s “Mumbai Meri Jaan”, starring Irrfan and R Madhavan.
Kamat also played a negative role in John Abraham-starrer “Rocky Handsome” in 2016, which he also directed.
His biggest hit was Ajay Devgn-Tabu starrer “Drishyam”, which was a remake of the Malayalam movie of the same name.