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Among 104,493 individuals, those who drank more than six cups of coffee per day had a 23 per cent lower risk of developing symptomatic gallstones compared with people who did not drink coffee, according to the study published in the Journal of Internal Medicine.
Drinking one extra cup of coffee per day was associated with three per cent lower risk, said researchers from the University of Copenhagen in Denmark.
Individuals with certain genetic variants that have been linked to increased coffee consumption had a lower risk of gallstones, they said.
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High coffee intake is associated observationally with low risk of GSD, and with genetic evidence to support a causal relationship, they said.