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Seif al-Islam submitted his candidacy papers in the southern town of Sabah, the agency said in a statement.
Gadhafi’s son was captured by fighters late in 2011, the year when a popular uprising toppled Gadhafi after more than 40 years in power. Moammar Gadhafi was later killed amid the ensuing fighting that would turn into a civil war.
Seif al-Islam was released in June 2017 after more than five years in detention.