Melbourne : Consuming a healthy diet rich in fibre during pregnancy may promote the wellbeing of both the mother and child, and reduce the risk of preeclampsia, according to a study. Plant-based fibre is broken down in the gut by bacteria into factors that influence the immune system, said researchers from the University of Sydney in Australia. The researchers investigated the role of these metabolic products of gut bacteria during pregnancy. They noted the simple recommendation to 'eat real food, mostly plants, and not too much' might be the most effective primary prevention strategy for some of the most serious conditions of our time. "The mother's gut bacteria and diet appear to be crucial to promoting a healthy pregnancy," said Professor Ralph Nanan, from the University of Sydney. The study, published in the journal Nature Communications, found that in humans, reduced levels of acetate, which is mainly produced by fibre fermentation in the gut, is associated with the common and serious pregnancy-related condition preeclampsia. Preeclampsia occurs in up to 10 per cent of pregnancies and is characterised by high blood pressure, protein in the urine and severe swelling in the mother. It also interferes with the child's immune development whilst in the womb, with some evidence suggesting a link to higher rates of allergies and autoimmune disease later in life. The study found that preeclampsia affected the development of an important foetal immune organ, the thymus, which sits just behind the breastbone. Foetuses in preeclamptic pregnancies were found to have a much smaller thymus than children from healthy pregnancies. The cells the thymus normally generates, called T cells (thymus-derived cells) -- specifically those associated with the prevention of allergies and autoimmune conditions such as diabetes -- also remained lower in infants after preeclampsia, even four years after delivery. The mechanisms of acetate on the developing foetal immune system were further examined in separate experiments involving mice that showed acetate was central in driving fetal thymus and T cell development. These results showed that promoting specific metabolic products of gut bacteria during pregnancy might be an effective way to maintain a healthy pregnancy and to prevent allergies and autoimmune conditions later in life. They may also, in part, explain the rapid increase of allergies and autoimmune conditions as Western diets are increasingly dominated by highly processed foods, which are very low in fibre, researchers said.
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