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Electing to bat, England lost its opening three wickets for 26 runs by the sixth over before Knight took control.
Only three other English batters could manage double figures — opener Sophia Dunkley (11), Amy Jones (2 ) and Charlie Dean (16 not out).
For India, spinners Saika Ishaque and Shreyanka Patil scalped three wickets each.
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Brief scores: England: 126 all out in 20 overs (Heather Knight 52; Shreyanka Patil 3 for 19, Saika Ishaque 3 for 22) vs India women.