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According to The Hollywood Reporter, the three actors join previously announced cast members Cillian Murphy, Emily Blunt, Robert Downey Jr and Matt Damon in the film.
The Universal Pictures project is a biopic of J Robert Oppenheimer, the theoretical physicist remembered as one of the fathers of the atom bomb.
Murphy is set to star as J Robert Oppenheimer and Emily Blunt as his wife Katherine.
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Safdie will play Edward Teller, the Hungarian physicist who is known as the father of the hydrogen bomb and a member of the Manhattan Project, the US research initiative that developed the first atomic bomb.
Malek will feature in the movie as a scientist.
”Oppenheimer” is based on the Pulitzer Prize-winning book ”American Prometheus: The Triumph and Tragedy of J Robert Oppenheimer” by Kai Bird and Martin J Sherwin.
Christopher Nolan will write and direct the film, while his creative partner and wife Emma Thomas will produce with Charles Roven of Atlas Entertainment.
The studio has described the film as an “epic thriller that thrusts audiences into the pulse-pounding paradox of the enigmatic man who must risk destroying the world in order to save it”.
Nolan’s last film was ”Tenet”, the 2020 globetrotting espionage film starring John David Washington, Robert Pattinson, Kenneth Branagh and Elizabeth Debicki, among others.