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The 30-share BSE index was trading 189.52 points or 0.37 per cent lower at 51,233.36 in initial deals, and the broader NSE Nifty fell 43.20 points or 0.28 per cent to 15,392.45.
M&M was the top loser in the Sensex pack, shedding more than 5 per cent, followed by Infosys, HDFC, IndusInd Bank, Tech Mahindra, L&T, NTPC and HCL Tech.
On the other hand, ITC, Asian Paints, Bharti Airtel and ICICI Bank were among the gainers.
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“There are two conflicting pieces of news for the market now. The steadily declining COVID fresh cases continue to be positive. Progressive unlocking has started in many states paving the way for a pick up in economic activity.
“But the negative news is rising fresh cases in countries like China & Vietnam. This might impact sentiments for Asian markets in general,” said V K Vijayakumar, Chief Investment Strategist at Geojit Financial Services.
Usually, when markets touch new highs, some consolidation with minor corrections happen even in bull markets. This can happen since Nifty touched new highs last Friday, Vijayakumar said.
Auto numbers of May will be very dismal and some market reaction can be expected in this segment. Banking appears to be on a strong wicket in the light of new reliefs announced for the MSME segment, he noted.
Foreign institutional investors (FIIs) were net buyers in the capital market as they bought shares worth 913.59 crore on Friday, as per provisional exchange data.
Equities on Wall Street closed higher in the overnight session.
Elsewhere in Asia, bourses in Shanghai, Hong Kong, Seoul and Tokyo were trading in negative territory in mid-session deals.
International oil benchmark Brent crude was trading 0.41 per cent higher at USD 69.00 per barrel.