Washington: Consuming curcumin — the active compound in turmeric — may improve exercise capacity in patients with heart failure, a study claims.
Curcumin has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds, said researchers from the University of Nebraska in the US.
Studies increasingly suggest that the compound may prevent or limit muscle wasting associated with a number of health conditions, including heart failure, they said.
People with heart failure have a reduced function of the left ventricle — the chamber of the heart that pumps blood out to the rest of the body — called reduced ejection fraction.
A decreased ability to exercise or exercise intolerance is another significant characteristic of heart failure, according to the study published in the Journal of Applied Physiology.
The researchers theorised that a reduction in the normal signalling of Nrf2, a protein that regulates the expression of antioxidant enzymes, may play a role in the impaired expression of antioxidant enzymes.
They examined the effects of curcumin, which is known to promote activation of Nrf2, on a mouse model of heart failure with reduced ejection fraction.
One group of mice with heart failure received daily doses of curcumin for 12 weeks, and another group did not receive treatment.
The heart failure groups were compared to a control group of healthy mice that received curcumin and an untreated control group.
The team measured the exercise capacity of all the mice before and after curcumin treatment.
The researchers also examined muscle fibre samples to assess enzyme expression levels.
They found that expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin.
In addition, both groups that received curcumin — even the animals without heart failure — had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure.
“These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve … quality of life” in people with heart failure with reduced ejection fraction, the researchers said.