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Advaith (29) and Ajmal (29), both working at a private hospital in the district, died in the accident that occurred at around 12.30 AM.
Three others who were travelling with them sustained injuries and are under treatment at a hospital nearby, they said.
Police said the driver apparently reached the area following the directions of the Google maps.
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The locals rushed to the spot to rescue and informed the fire service personnel and police.
A local resident told the media that three passengers, including a woman, were rescued by them.
A scuba diving team was pressed into service by the authorities to recover the bodies of the two deceased doctors.
The condition of those undergoing treatment is said to be stable.