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The group of labourers was returning from Punjab to Moradabad for Holi festival.
The pickup truck in which they were travelling was by a speeding truck near a village under Phugana police station, Deputy Superintendent of police (DSP) Sharad Sharma said.
The deceased were identified as 35-year old Vedram and his 10-year-old daughter Chavi, he said, adding that some of the injured labourers are in a critical condition.