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The resignation came hours before Prime Minister Narendra Modi carries out a major expansion and reshuffle of his Council of Ministers in which 43 new members are expected to take oath.
Besides Vardhan, Education Minister Ramesh Pokhriyal Nishank and Chemicals and Fertilizers Minister D V Sadananda Gowda are two other Cabinet ministers who have quit. Several union ministers of state have also resigned.
Vardhan, a doctor himself, had been in charge of the health ministry as well as the science and technology ministry as the Covid pandemic broke and then India worked to develop vaccines.
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