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The Netflix series will see “The Big Bang Theory” star play the role of a talent agent named Henry Willson, reported TV Line.
Also joining the cast as series regulars are Dylan McDermott, Joe Mantello, Holland Taylor, Samara Weaving, Maude Apatow, Jake Picking and Laura Harrier.
Previously announced cast includes Patti LuPone, Darren Criss, David Corenswet and Jeremy Pope.
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He has co-created the show with frequent collaborator Ian Brennan.
“Hollywood” started production earlier this year.
It is the third project Murphy has created for Netflix following “The Politician” and “Ratched”.