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The incident took place at Mankoli junction in Bhiwandi town on Mumbai-Nashik highway on Thursday afternoon, they said.
The deceased were identified as Devikabai Balaram Kakade (48) and her son Nitin, police said.
“They were returning home to Ambepada on a two-wheeler after having darshan of the Lord Ganesh idol installed at the house of the woman’s daughter in nearby Purna village.
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They came under a speeding vehicle that was coming from behind,” an official said.
The victims were rushed to a hospital, where the doctors declared them brought dead, he said, adding that the bodies were later sent for post-mortem.
A case has been registered against an unidentified driver of the vehicle under relevant sections of the Indian Penal Code (IPC) and the Motor Vehicles Act at Narpoli police station and further investigation is on, he said.