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Unabated foreign fund outflows and the rupee hitting an all-time low also weighed on sentiment.
The 30-share BSE Sensex settled 364.91 points or 0.67 percent lower at 54,470.67. During the day, it tanked 917.56 points or 1.67 percent to 53,918.02.
The NSE Nifty fell 109.40 points or 0.67 percent to end at 16,301.85.
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PowerGrid, HCL Technologies, Infosys, Maruti, and Bajaj Finserv were among the gainers.
Elsewhere in Asia, markets in Tokyo and Seoul settled lower, while Shanghai ended higher. Markets were closed in Hong Kong for a holiday.
Bourses in Europe were also quoting lower in the afternoon session.
Stock exchanges in the US had fallen on Friday.
Meanwhile, international oil benchmark Brent crude declined 1.17 percent to USD 111 per barrel.
Foreign institutional investors offloaded shares worth a net Rs 5,517.08 crore on Friday, according to stock exchange data.