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The 30-share BSE Sensex fell 111.85 points to 81,809.44. The NSE Nifty dipped 39.2 points to 25,001.90.
Among the 30 Sensex firms, Tata Motors, ICICI Bank, Titan, HDFC Bank, JSW Steel, Tech Mahindra, UltraTech Cement and Axis Bank were the major laggards.
Asian Paints, Bharti Airtel, ITC and Hindustan Unilever were among the gainers.
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The US markets ended mostly with gains on Tuesday.
Foreign Institutional Investors (FIIs) bought equities worth Rs 2,208.23 crore on Tuesday, according to exchange data.
Global oil benchmark Brent crude climbed 0.59 per cent to USD 69.60 a barrel.
The BSE benchmark climbed 361.75 points or 0.44 per cent to settle at 81,921.29 on Tuesday. The NSE Nifty surged 104.70 points or 0.42 per cent to 25,041.10.