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The plane, which was on a 15-minute scheduled flight to the mountain town of Jomsom, lost contact with the airport tower shortly after takeoff.
Police official Ramesh Thapa said there was no information on the Twin Otter aircraft and a search was underway.
It has been raining in the area for the past few days but flights have been operating normally. Planes on that route fly between mountains before landing in a valley.
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