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After a volatile trading session, the 30-share index ended 112.16 points or 0.19 per cent lower at 60,433.45. Similarly, the NSE Nifty fell 24.30 points or 0.13 per cent to 18,044.25.
HDFC Bank was the top loser in the Sensex pack, shedding nearly 2 per cent, followed by HDFC, Bajaj Finance, NTPC, Maruti, Kotak Bank and PowerGrid.
On the other hand, M&M, SBI, Reliance Industries and ICICI Bank were among the gainers.
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Despite the passage of the long-awaited infrastructure bill, the gains in the US market were capped as investors cautiously awaited the US inflation data, he stated.
Elsewhere in Asia, bourses in Shanghai, Hong Kong and Seoul ended in a positive note, while Tokyo was in the red.
Major indices in Europe were also trading with gains in mid-session deals.
Meanwhile, international oil benchmark Brent crude rose 0.91 per cent to USD 84.19 per barrel.