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Emergency services said at least four people have been injured in the incidents. There are no reports of any fatalities.
Greater Manchester Police (GMP) said a man has been arrested on suspicion of serious assault but inquiries are on.
There is no indication of a terrorism link to the incident at the Arndale Shopping Centre in Manchester city centre, the police said.
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A man in his 40s has been arrested on suspicion of serious assault. He has been taken to custody for questioning, the statement said.
The shopping centre was evacuated as police responded to reports of the stabbings.
Social media posts show a large number of officers at the scene and the suspect being tasered.