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The aircraft crashed after taking off from the Olaya Herrera Airport, Colombian aviation officials said in a statement.
The victims were identified as six passengers and two crew members. It was not immediately clear if more than eight people were on the plane.
The exact cause of the crash has not yet been determined. Medellín Mayor Daniel Quintero said in a statement that the aircraft experienced ”an engine failure” during takeoff.
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The aircraft was travelling to the western department of Chocó. (AP)