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In a statement, Assad’s office said the first couple did PCR tests after they felt minor symptoms consistent with the COVID-19 illness.
It said that Assad, 55, and his wife Asma, will return to work after spending between two to three weeks in isolation in their home.
Both were in “good health and in stable condition,” it added.
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Syria began a vaccination campaign last week, but no details have been given about the process.
The health minister said the government procured the vaccines from a friendly country, which he declined to name.
The announcement comes days after international and Israeli media reports revealed that Israel paid Russia USD 1.2 million to provide the Syrian government with the anti-novel coronavirus vaccines, as part of a deal that secured the release of an Israeli woman held in Damascus.
The terms of the clandestine trade-off negotiated by Moscow remained murky; Damascus denied it happened and Russia had no comment.
It was not immediately clear if Assad and his family members have been vaccinated.