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Scientists will begin recruiting some 6,000 people across the U.K. on Monday for the 12-month trial.
Dr. Saul Faust, who is helping lead the study, said the research will start first in Britain but aims to recruit a total of 30,000 people in six countries around the world.
The shot uses a harmless cold virus to deliver the spike protein of the coronavirus into the body, which scientists hope will prompt an immune response.
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“It”s fantastic news that vaccines aimed at the spike protein can prevent coronavirus disease,” Faust, a professor of pediatric immunology and infectious diseases at the University of Southampton, said at a news briefing.
“We just don”t know how each of these vaccines is going to behave and which are going to generate the better short and long-term immunity,” he added.
Faust said half of the people in the new U.K. study will be given a placebo vaccine of saline.
He added that researchers are hoping to recruit people from groups disproportionately affected by COVID-19, including older people and those of ethnic minorities.
The Jannsen vaccine is among the six experimental coronavirus vaccines that Britain has ordered as part of a planned 350 million-dose stockpile.