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The accident took place when a speedy trailer rammed into a bus, carrying people from a wedding party, in Hala area of Hyderabad district, the police said.
The bus had stopped on the National Highway to change a deflated tyre when the speeding trailer bumped into it from behind, they said. The police said 18 people were killed in the accident.
Officials at the Edhi ambulance service said that they shifted 30 injured to Hala and Hyderabad civil hospitals. Road accidents are common in Pakistan. Most of them are caused due to reckless driving and bad roads.