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Peter Knudson with the National Transportation Safety Board tells The Associated Press 12 people were aboard the Pilatus PC-12 when it crashed about 12:30 pm on Saturday, shortly after taking off from Chamberlain, about 140 miles (225.3 kilometers) west of Sioux Falls.
Knudson says nine people were killed and three were injured. The single-engine plane was bound for Idaho Falls, Idaho.
Media reports say Chamberlain and central south-central South Dakota were under a winter storm warning at the time of the crash.
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No further information was immediately available.