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The deceased persons were identified as 52-year-old Brindaban Karmakar, a cloth merchant, his wife Debasree Karmakar, who was in her forties, their 17-year-old daughter Debaleena and eight-year-old son Utsaha, a police officer said.
The bodies were found on Sunday in the closed apartment on M S Mukherjee Road in Khardah area.
The police suspect that the man murdered his family members by poisoning them and then died by suicide.
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A suicide note was also found, in which the man claimed that his wife had an extra-marital affair and he could not bear it, hence he took the extreme step, the officer said.
Locals said the police after they found a foul smell emanating from the apartment. The door had to be broken open as it was bolted from inside, he said.
A forensic team visited the spot, and further investigation is underway, the officer added.