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The two-part show hails from BBC One, Mammoth Screen and Agatha Christie Limited, the company said in a statement.
Scodelario, who most recently featured in disaster horror “Crawl”, will portray Hermia. Sewell, best known for starring in Amazon’s “The Man In The High Castle”, will take on the role of Mark Easterbrook.
The story follows Easterbrook as he tries to uncover the mystery of a list of names found in the shoe of a dead woman.
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The show will also feature Bertie Carvel, Sean Pertwee, Henry Lloyd-Hughes, Poppy Gilbert, Madeleine Bowyer and Ellen Robertson.
Sarah Woodward, Georgina Campbell, Claire Skinner, Rita Tushingham, Sheila Atim and Kathy Kiera Clarke complete the cast.
Leonora Lonsdale is directing the series which started filming in and around the UK’s Bristol area. Ado Yoshizaki Cassuto is producing.
Amazon Prime Video is the US co-production partner, and Endeavor Content will handle sales in all territories internationally.