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For patients with deep skin wounds, all three skin layers – the epidermis, dermis and hypodermis – may be heavily damaged.
The current preferred treatment is called split-thickness skin grafting, where healthy donor skin is grafted onto the surface epidermis and part of the underlying dermis.
Split-thickness grafting on large wounds requires enough healthy donor skin to traverse all three layers, and sufficient graft skin is rarely available. This leaves a portion of the wounded area “ungrafted” or uncovered, leading to poor healing outcomes.
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