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The incident happened when a tempo collided with a lorry.
The deceased are said to be daily wage workers from various parts of Raichur district and were on their way to Bengaluru, sources said.
The injured have been shifted to the hospital for treatment.
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Home Minister Araga Jnanendra, who is also Tumakuru district in-charge, in a statement said he has spoken to the district Deputy Commissioner and Superintendent of Police and had instructed them to see to it that necessary treatment is provided to the injured.